This book constitutes the refereed proceedings of the 6th IFIP WG 6.6 International Conference on Autonomous Infrastructure, Management, and Security, AIMS 2012, held in Luxembourg in June 2012. The 10 full papers presented were carefully reviewed and selected from 23 submissions. They cover autonomic and distributed management, network security, network monitoring, and special environments and Internet of Things. In addition, this book contains 9 workshop papers which were selected from 18 submissions. They deal with high-speed networks and network management, intrusion detection, and network monitoring and security.