The Internet of things (IoT) is a network of connected physical objects or things that are working along with sensors, wireless transceiver modules, processors, and software required for connecting, processing, and exchanging data among the other devices over the Internet. These objects or things are devices ranging from simple handheld devices to complex industrial heavy machines. A thing in IoT can be any living or non-living object that can be provided capabilities to sense, process, and exchange data over a network. The IoT provides people with the ability to handle their household works to industrial tasks smartly and efficiently without the intervention of another human. The IoT provides smart devices for home automation as well as business solutions for delivering insights into everything from real-time monitoring of working systems to supply chain and logistics operations. The IoT has become one of the most prominent technological inventions of the 21st century. Due to the versatility of IoT devices, there are numerous real-world applications of the IoT in various domains such as smart home, smart city, health care, agriculture, industry, and transportation. The IoT has emerged as a paradigm-shifting technology that is influencing various industries. Many companies, governments, and civic bodies are shifting to IoT applications to improve their works and to become more efficient. The world is slowly transforming toward a “smart world” with smart devices. As a consequence, it shows many new opportunities coming up in the near “smart” future for IoT professionals. Therefore, there is a need to keep track of advancements related to IoT applications and further investigate several research challenges related to the applicability of IoT in different domains to make it more adaptable for practical and industrial use. With this goal, this book provides the most recent and prominent applications of IoT in different domains as well as issues and challenges in developing IoT applications for various new domains.